Intestinal mucosal defense system, Part 1. Consensus recommendations for immunonutrients

Creators: Neu, Josef and Mihatsch, Walter A. and Zegarra, Jaime and Supapannachart, Sarayut and Ding, Zong-Yi and Murguia-Peniche, Teresa
Title: Intestinal mucosal defense system, Part 1. Consensus recommendations for immunonutrients
Item Type: Article or issue of a publication series
Journal or Series Title: The journal of pediatrics
Page Range: S56-S63
Date: March 2013
Divisions: Gesundheitsmanagement
Abstract: When microbial communities colonize in the developing intestinal tract after birth, microorganisms interact with specific apical surface receptors on the enterocytes. This interaction triggers a response that prevents overexpression of inflammatory cytokines, thus providing protection from pathogen-induced mucosal damage. Multiple immune modulatory factors in human milk and innate humoral factors also control inflammatory responses, providing additional protective effects. Our understanding of the role of the luminal microbial communities or microbiota is growing rapidly as novel technologies provide new insights into their taxonomy, function during early development, and impact on life-long health. Multiple studies have evaluated the effects of the specific nutrients, glutamine, arginine, nucleotides, polyunsaturated fatty acids, and lactoferrin, on disease outcomes in premature infants. These studies support a role for nutrients to modulate host defense mechanisms in premature infants, to develop normal digestive function, to protect from bacterial translocation, and to preserve mucosal barrier integrity. These effects are clearly important. However, not enough is yet known to design specific clinical care practices that support a healthy microbiota.
Forthcoming: No
Citation:

Neu, Josef and Mihatsch, Walter A. and Zegarra, Jaime and Supapannachart, Sarayut and Ding, Zong-Yi and Murguia-Peniche, Teresa (2013) Intestinal mucosal defense system, Part 1. Consensus recommendations for immunonutrients. The journal of pediatrics, 162 (3, S). S56-S63. ISSN 1097-6833

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