Reference values for urinary calcium and phosphorus to prevent osteopenia of prematurity

Creators: Pohlandt, Frank and Mihatsch, Walter A.
Title: Reference values for urinary calcium and phosphorus to prevent osteopenia of prematurity
Item Type: Article or issue of a publication series
Journal or Series Title: Pediatric nephrology : journal of the International Pediatric Nephrology Association
Page Range: pp. 1192-1193
Date: 2004
Divisions: Gesundheitsmanagement
Abstract: The prevention of osteopenia of prematurity is an important issue in the care of preterm infants. Fetal bone mineral accretion has been achieved in preterm infants by establishing and maintaining a simultaneous slight excretion of calcium (Ca) and phosphorus (P) (urine concentrations of 1-2 mmol/l) by means of an individual supplementation with Ca and/or P, resulting in a slight surplus supply (SSS). In this issue, Aladangady et al. present associations between urinary Ca/Cr and PO(4)/Cr ratios of preterm infants and biochemical variables of bone mineral metabolism. However, to date it has not been proven that these variables are a reliable substitute for direct measurement of bone mineral content (BMC). Before Ca/Cr and PO(4)/Cr ratios can be recommended as a new reference for improving BMC, the following steps are required: (1) direct measurement of BMC, (2) a prospective interventional trial to test and compare this new reference with the existing one (SSS, urinary Ca and P of 1-2 mmol/l) investigating BMC as primary outcome, and (3) adequate proof that Ca and P/Cr ratios are superior to simple urinary Ca and P concentrations.
Forthcoming: No
Citation:

Pohlandt, Frank and Mihatsch, Walter A. (2004) Reference values for urinary calcium and phosphorus to prevent osteopenia of prematurity. Pediatric nephrology : journal of the International Pediatric Nephrology Association, 19 (11). pp. 1192-1193. ISSN 0931-041X

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