Treatment with antioxidants does not prevent loss of dopamine in the striatum of MPTP-treated common marmosets: Preliminary observations

Creators: Mihatsch, Walter and Russ, Hermann and Gerlach, Manfred and Riederer, Peter and Przuntek, Horst
Title: Treatment with antioxidants does not prevent loss of dopamine in the striatum of MPTP-treated common marmosets: Preliminary observations
Item Type: Article or issue of a publication series
Journal or Series Title: Journal of neural transmission / Parkinson's disease and dementia section
Page Range: pp. 73-78
Date: March 1991
Divisions: Gesundheitsmanagement
Abstract: Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to common marmosets causes a profound loss of dopamine and serotonin in the striatum. Additional daily systemic treatment of monkeys with the antioxidants ascorbic acid (100 mg/kg) and α-tocopherol (2,350 mg/kg) prior to, during and following administration of MPTP does not prevent the loss of dopamine and serotonin in the striatum, suggesting that these antioxidants are unable to protect dopaminergic neurones against neurotoxicity of MPTP
Forthcoming: No
Citation:

Mihatsch, Walter and Russ, Hermann and Gerlach, Manfred and Riederer, Peter and Przuntek, Horst (1991) Treatment with antioxidants does not prevent loss of dopamine in the striatum of MPTP-treated common marmosets: Preliminary observations. Journal of neural transmission / Parkinson's disease and dementia section, 3 (1). pp. 73-78. ISSN 0300-9564

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