Neurochemical and behavioural features induced by chronic low dose treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the common marmoset: implications for Parkinson's disease?

Creators: Russ, Hermann and Mihatsch, Walter and Gerlach, Manfred and Riederer, Peter and Przuntek, Horst
Title: Neurochemical and behavioural features induced by chronic low dose treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the common marmoset: implications for Parkinson's disease?
Item Type: Article or issue of a publication series
Journal or Series Title: Neuroscience Letters
Page Range: pp. 115-118
Date: February 1991
Divisions: Gesundheitsmanagement
Abstract: Protracted long-term treatment of common marmosets with 15 doses (0.5–4.5 mg/kg, i.p.) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; total dose 25 mg/kg, given over 29 days) caused transitory changes in motor behaviour reminiscent of human Parkinson's disease. 16 days from the start of MPTP administration, all animals showed motor impairment, consisting of profound akinesia and a rigid posture, but in no case resting tremor. Biogenic amines were measured in nigrostriatal regions one month after finishing MPTP treatment. There was a profound loss of dopamine and serotonin in the substantia nigra and in the striatum; noradrenaline was only reduced in the putamen. Continuous analyses of the concentrations of biogenic amine metabolites in the CSF during this study revealed persistent dopaminergic disturbances and temporary alterations in serotoninergic and noradrenergic function.
Forthcoming: No
Citation:

Russ, Hermann and Mihatsch, Walter and Gerlach, Manfred and Riederer, Peter and Przuntek, Horst (1991) Neurochemical and behavioural features induced by chronic low dose treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the common marmoset: implications for Parkinson's disease? Neuroscience Letters, 123 (1). pp. 115-118. ISSN 1872-7972

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